MS as a disconnection syndrome

Dineen RA et al.  Disconnection as a mechanism for cognitive dysfunction in multiple sclerosis.  Brain 2009;132: 239-249

Authors use DTI MRI and neuropsychology to try to correlate white matter specific disconnections with cognitive disorders in MS.Without delving into methodology, PASAT scores correlated with splenium and body of corpus callosum, parieto-occipital radiations of the forceps major, left cingulum, the right inferior longitudinal fasciculus running into the left temporal lobe, parietal tracts and portions of the left superior longitudinal fasciculus, and the parietal arcs of the arcuate fasciculi bilaterally.

The Benton Visual Retention Test correlated with lesions in splenium and body of the corpus callosum, the parietal and occipital projections of the forceps major bilaterally, the left inferior longitudinal fasciculus running into the temporal lobe, the left arcuate fasciculus, the left cingulum, the anterior portion and tail of the fornix, the white matter of the right parietal and medial occipital lobes.  Te right temporal lobe figured prominently with adjustment for IQ. 

CVLT II-- correlations with the body and splenium of the corpus callosum, the parietal and occipital projections of the forceps major bilaterally, the parietal portion of the left superior longitudinal fasciculus, the left inferior longitudinal fasciculus and arcuate fasciculus, the left posterior fornix and cingulum running from the temporal lobe. 

No correlations found for the following tests: JLO, COWAT, DST CS.