Behavioral neurology 2.0 of white matter
Smith EE et al. Correlations between MRI white matter lesion location and executive function and episodic memory. Neurology 2011; 76:1492-1499.
Elderly patients (n=160, 147 analyzed) who were 65+ with mild cognitive impairment underwent a 22 item neuropsychological test .
Areas associated with decline in executive function score: bilateral inferior frontal lobe white matter (uncinate fasciculus), inferior longitudinal fasciculus and superior longitudinal fasciculus,
cingulum bindle, bundle of Muratoff on left.
Comment-- as with prior lesion studies in MRI one wonders about radiology technique, ie what about NAWM (normal appearing white matter) and whether this technique captures the anatomy of the disease. Still its a well done study that captures the imagination for behavioral neurology 2.0, behavioral neurology of the white matter.
Smith EE et al. Correlations between MRI white matter lesion location and executive function and episodic memory. Neurology 2011; 76:1492-1499.
Elderly patients (n=160, 147 analyzed) who were 65+ with mild cognitive impairment underwent a 22 item neuropsychological test .
Areas associated with decline in executive function score: bilateral inferior frontal lobe white matter (uncinate fasciculus), inferior longitudinal fasciculus and superior longitudinal fasciculus,
cingulum bindle, bundle of Muratoff on left.
Comment-- as with prior lesion studies in MRI one wonders about radiology technique, ie what about NAWM (normal appearing white matter) and whether this technique captures the anatomy of the disease. Still its a well done study that captures the imagination for behavioral neurology 2.0, behavioral neurology of the white matter.
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