Neuropsych abnormalities in pre-HD

from Duff et al.  Neurology 2010; 75:500-507

 

Authors found linear trends with SDMT affected first, then episodic memory (trial four or delay trial of HVLT, with facial recognition less affected and Color Trails less affected. Authors used raw scores, and found most patients had nonamnestic MCI in a single domain, not multiple domain.  Conclusion was that these tests are important markers for future trials of neuroprotection.